Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) (NM_000414) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD) . An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Synonyms
DBP; MFE-2; MFP-2; MPF-2; PRLTS1; SDR8C1
Gene ID
3295
UniProt
P51659, A0A0S2Z4J1, B2R659
Accession Number mRNA
NM_000414
Chromosomal Location
5q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Primary bile acid biosynthesis
Field of Research
Metabolic pathways, Primary bile acid biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
79.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HSD17B4
Species
Human
Protein ID
NP_000405
Overview
Recombinant protein of human hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3295
Uniprot URL
https://www.uniprot.org/uniprot/P51659
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000414
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000405
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