Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) (NM_000414) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD) . An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Overview

Recombinant protein of human hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4)

Synonyms

DBP; MFE-2; MFP-2; MPF-2; PRLTS1; SDR8C1

Gene ID

3295

UniProt

P51659, A0A0S2Z4J1, B2R659

Accession Number mRNA

NM_000414

Chromosomal Location

5q23.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Primary bile acid biosynthesis

Field of Research

Metabolic pathways, Primary bile acid biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

79.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.