PRMT2 (NM_206962) Human Recombinant Protein

Product Specifications

Background

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR) -mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER) -mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner) . May be involved in growth regulation.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human protein arginine methyltransferase 2 (PRMT2), transcript variant 1

Synonyms

HRMT1L1

Gene ID

3275

UniProt

P55345, A0A0S2Z3N3

Accession Number mRNA

NM_206962

Chromosomal Location

21q22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

48.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.