GSK3 beta (GSK3B) (NM_002093) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Synonyms
Glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform
Gene ID
2932
UniProt
P49841
Accession Number mRNA
NM_002093
Chromosomal Location
3q13.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Axon guidance, Basal cell carcinoma, B cell receptor signaling pathway, Cell cycle, Chemokine signaling pathway, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Hedgehog signaling pathway, Insulin signaling pathway, Melanogenesis, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, T cell receptor signaling pathway, Wnt signaling pathway
Field of Research
Alzheimer's disease, Axon guidance, Basal cell carcinoma, B cell receptor signaling pathway, Cell cycle, Chemokine signaling pathway, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Hedgehog signaling pathway, Insulin signaling pathway, Melanogenesis, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, T cell receptor signaling pathway, Wnt signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
47.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GSK3B
Species
Human
Protein ID
NP_002084
Overview
Recombinant protein of human glycogen synthase kinase 3 beta (GSK3B)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2932
Uniprot URL
https://www.uniprot.org/uniprot/P49841
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002093
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002084
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