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CDK1 (NM_001786) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Synonyms

CDC2; CDC28A; P34CDC2

Gene ID

983

UniProt

P06493, I6L9I5

Accession Number mRNA

NM_001786

Chromosomal Location

10q21.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cell cycle, Gap junction, Oocyte meiosis, p53 signaling pathway, Progesterone-mediated oocyte maturation

Field of Research

Cell cycle, Gap junction, Oocyte meiosis, p53 signaling pathway, Progesterone-mediated oocyte maturation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase, Stem cell - Pluripotency

Molecular Weight

33.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CDK1

Species

Human

Protein ID

NP_001777

Overview

Recombinant protein of human cell division cycle 2, G1 to S and G2 to M (CDC2), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/983

Uniprot URL

https://www.uniprot.org/uniprot/P06493

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001786

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001777

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