CDC25A (NM_001789) Human Recombinant Protein
Product Specifications
Background
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CDC25A2
Gene ID
993
UniProt
P30304
Accession Number mRNA
NM_001789
Chromosomal Location
3p21.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell cycle, Progesterone-mediated oocyte maturation
Field of Research
Cell cycle, Progesterone-mediated oocyte maturation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Phosphatase
Molecular Weight
58.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CDC25A
Species
Human
Protein ID
NP_001780
Overview
Recombinant protein of human cell division cycle 25 homolog A (S. pombe) (CDC25A), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/993
Uniprot URL
https://www.uniprot.org/uniprot/P30304
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001789
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001780
Curated Selection
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