AKR1B1 (NM_001628) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Synonyms
ADR; ALDR1; ALR2; AR
Gene ID
231
UniProt
P15121, A0A024R7A8
Accession Number mRNA
NM_001628
Chromosomal Location
7q33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Fructose and mannose metabolism, Galactose metabolism, Glycerolipid metabolism, Metabolic pathways, Pentose and glucuronate interconversions, Pyruvate metabolism
Field of Research
Fructose and mannose metabolism, Galactose metabolism, Glycerolipid metabolism, Metabolic pathways, Pentose and glucuronate interconversions, Pyruvate metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
35.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AKR1B1
Species
Human
Protein ID
NP_001619
Overview
Purified recombinant protein of Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/231
Uniprot URL
https://www.uniprot.org/uniprot/P15121
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001628
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001619
Curated Selection
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