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AKR1B1 (NM_001628) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Overview

Purified recombinant protein of Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1)

Synonyms

ADR; ALDR1; ALR2; AR

Gene ID

231

UniProt

P15121, A0A024R7A8

Accession Number mRNA

NM_001628

Chromosomal Location

7q33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Fructose and mannose metabolism, Galactose metabolism, Glycerolipid metabolism, Metabolic pathways, Pentose and glucuronate interconversions, Pyruvate metabolism

Field of Research

Fructose and mannose metabolism, Galactose metabolism, Glycerolipid metabolism, Metabolic pathways, Pentose and glucuronate interconversions, Pyruvate metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

35.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

AKR1B1

Species

Human

Protein ID

NP_001619

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/231

Uniprot URL

https://www.uniprot.org/uniprot/P15121

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001628

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001619

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