MCL1 (NM_021960) Human Recombinant Protein
Product Specifications
Background
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Synonyms
Bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
Gene ID
4170
UniProt
Q07820
Accession Number mRNA
NM_021960
Chromosomal Location
1q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
37.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MCL1
Species
Human
Protein ID
NP_068779
Overview
Purified recombinant protein of Homo sapiens myeloid cell leukemia sequence 1 (BCL2-related) (MCL1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4170
Uniprot URL
https://www.uniprot.org/uniprot/Q07820
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021960
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_068779
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