Epoxide hydrolase (EPHX1) (NM_000120) Human Recombinant Protein
Product Specifications
Background
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Synonyms
EPHX; EPOX; HYL1; MEH
Gene ID
2052
UniProt
P07099, R4SBI6
Accession Number mRNA
NM_000120
Chromosomal Location
1q42.12
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolism of xenobiotics by cytochrome P450
Field of Research
Metabolism of xenobiotics by cytochrome P450
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
52.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EPHX1
Species
Human
Protein ID
NP_000111
Overview
Recombinant protein of human epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2052
Uniprot URL
https://www.uniprot.org/uniprot/P07099
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000120
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000111
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