Epoxide hydrolase (EPHX1) (NM_000120) Human Recombinant Protein

Product Specifications

Background

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

Overview

Recombinant protein of human epoxide hydrolase 1, microsomal (xenobiotic) (EPHX1), transcript variant 1

Synonyms

EPHX; EPOX; HYL1; MEH

Gene ID

2052

UniProt

P07099, R4SBI6

Accession Number mRNA

NM_000120

Chromosomal Location

1q42.12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolism of xenobiotics by cytochrome P450

Field of Research

Metabolism of xenobiotics by cytochrome P450

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

52.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.