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NDUFV2 (NM_021074) Human Recombinant Protein

Product Specifications

Background

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]

Synonyms

CI-24k; MC1DN7

Gene ID

4729

UniProt

P19404

Accession Number mRNA

NM_021074

Chromosomal Location

18p11.22

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

23.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NDUFV2

Species

Human

Protein ID

NP_066552

Overview

Recombinant protein of human NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2), nuclear gene encoding mitochondrial protein

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4729

Uniprot URL

https://www.uniprot.org/uniprot/P19404

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_021074

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_066552

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