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IFNGR2 (NM_005534) Human Recombinant Protein

Selected Variant

PH41880M5

Size: 20 µg

Product Specifications

Background

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2)

Synonyms

AF-1; IFGR2; IFNGT1; IMD28

Gene ID

3460

UniProt

P38484, A8K881

Accession Number mRNA

NM_005534

Chromosomal Location

21q22.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

Field of Research

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

35 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

IFNGR2

Species

Human

Protein ID

NP_005525

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3460

Uniprot URL

https://www.uniprot.org/uniprot/P38484

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005534

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005525

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