PCLAF (NM_014736) Human Recombinant Protein
Product Specifications
Background
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human KIAA0101 (KIAA0101), transcript variant 1
Synonyms
KIAA0101; L5; NS5ATP9; OEATC; OEATC-1; OEATC1; p15 (PAF) ; p15/PAF; p15PAF; PAF; PAF15
Gene ID
9768
UniProt
Q15004
Accession Number mRNA
NM_014736
Chromosomal Location
15q22.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
11.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PCLAF
Species
Human
Protein ID
NP_055551
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9768
Uniprot URL
https://www.uniprot.org/uniprot/Q15004
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014736
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055551
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