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PFKM (NM_000289) Human Recombinant Protein

Product Specifications

Background

Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Synonyms

ATP-PFK; GSD7; PFK-1; PFK-A; PFK1; PFKA; PFKX; PPP1R122

Gene ID

5213

UniProt

P08237, A0A024R0Y5

Accession Number mRNA

NM_000289

Chromosomal Location

12q13.11

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Fructose and mannose metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Pentose phosphate pathway

Field of Research

Fructose and mannose metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Pentose phosphate pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

85 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PFKM

Species

Human

Protein ID

NP_000280

Overview

Recombinant protein of human phosphofructokinase, muscle (PFKM)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5213

Uniprot URL

https://www.uniprot.org/uniprot/P08237

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000289

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000280

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