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S adenosylhomocysteine hydrolase (AHCY) (NM_000687) Human Recombinant Protein

Selected Variant

PH41851M5

Size: 20 µg

Product Specifications

Background

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy) . Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Overview

Recombinant protein of human S-adenosylhomocysteine hydrolase (AHCY)

Synonyms

AdoHcyase; SAHH

Gene ID

191

UniProt

P23526, A0A384MTQ3

Accession Number mRNA

NM_000687

Chromosomal Location

20q11.22

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cysteine and methionine metabolism, Metabolic pathways, Selenoamino acid metabolism

Field of Research

Cysteine and methionine metabolism, Metabolic pathways, Selenoamino acid metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

47.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

AHCY

Species

Human

Protein ID

NP_000678

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/191

Uniprot URL

https://www.uniprot.org/uniprot/P23526

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000687

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000678

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