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RRM1 (NM_001033) Human Recombinant Protein

Product Specifications

Background

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Overview

Recombinant protein of human ribonucleotide reductase M1 (RRM1)

Synonyms

R1; RIR1; RR1

Gene ID

6240

UniProt

P23921

Accession Number mRNA

NM_001033

Chromosomal Location

11p15.4

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Field of Research

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

29765556

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

89.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

RRM1

Species

Human

Protein ID

NP_001024

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6240

Uniprot URL

https://www.uniprot.org/uniprot/P23921

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001033

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001024

Frequently Asked Questions

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