A RAF (ARAF) (NM_001654) Human Recombinant Protein
Product Specifications
Background
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Overview
Recombinant protein of human v-raf murine sarcoma 3611 viral oncogene homolog (ARAF)
Synonyms
A-RAF; ARAF1; PKS2; RAFA1
Gene ID
369
UniProt
P10398, A0A024R178
Accession Number mRNA
NM_001654
Chromosomal Location
Xp11.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Acute myeloid leukemia, Bladder cancer, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Glioma, Insulin signaling pathway, Long-term depression, Long-term potentiation, Melanoma, Natural killer cell mediated cytotoxicity, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Vascular smooth muscle contraction
Field of Research
Acute myeloid leukemia, Bladder cancer, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Glioma, Insulin signaling pathway, Long-term depression, Long-term potentiation, Melanoma, Natural killer cell mediated cytotoxicity, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Vascular smooth muscle contraction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
67.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ARAF
Species
Human
Protein ID
NP_001645
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/369
Uniprot URL
https://www.uniprot.org/uniprot/P10398
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001654
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001645
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