SOX2 (NM_003106) Human Recombinant Protein
Product Specifications
Background
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT) . [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human SRY (sex determining region Y) -box 2 (SOX2)
Synonyms
ANOP3; MCOPS3
Gene ID
6657
UniProt
P48431, A0A0U3FYV6
Accession Number mRNA
NM_003106
Chromosomal Location
3q26.33
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
25892221
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Adult stem cells, Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Molecular Weight
34.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SOX2
Species
Human
Protein ID
NP_003097
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6657
Uniprot URL
https://www.uniprot.org/uniprot/P48431
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003106
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003097
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