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SOX2 (NM_003106) Human Recombinant Protein

Product Specifications

Background

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT) . [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human SRY (sex determining region Y) -box 2 (SOX2)

Synonyms

ANOP3; MCOPS3

Gene ID

6657

UniProt

P48431, A0A0U3FYV6

Accession Number mRNA

NM_003106

Chromosomal Location

3q26.33

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

25892221

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Adult stem cells, Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

Molecular Weight

34.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SOX2

Species

Human

Protein ID

NP_003097

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6657

Uniprot URL

https://www.uniprot.org/uniprot/P48431

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003106

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003097

Frequently Asked Questions

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