C1orf135 (AUNIP) (NM_024037) Human Recombinant Protein
Product Specifications
Background
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561) . Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561) . Inhibits non-homologous end joining (NHEJ) (PubMed:29042561) . Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670) .[UniProtKB/Swiss-Prot Function]
Synonyms
AIBP; C1orf135
Gene ID
79000
UniProt
Q9H7T9
Accession Number mRNA
NM_024037
Chromosomal Location
1p36.11
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
40.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AUNIP
Species
Human
Protein ID
NP_076942
Overview
Recombinant protein of human chromosome 1 open reading frame 135 (C1orf135)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/79000
Uniprot URL
https://www.uniprot.org/uniprot/Q9H7T9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_024037
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_076942
Curated Selection
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