CCG-50014

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

Product Specifications

CAS Number

[883050-24-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RGS Protein

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ccg-50014.html

Concentration

10mM

Purity

99.62

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

Molecular Formula

C16H13FN2O2S

Molecular Weight

316.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50 (15) :3181-92.|[2]Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120 (3) :671-7.