DARPP32 (PPP1R1B) (NM_181505) Human Recombinant Protein
Product Specifications
Background
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Overview
Recombinant protein of human protein phosphatase 1, regulatory (inhibitor) subunit 1B (PPP1R1B), transcript variant 2
Synonyms
DARPP-32; DARPP32
Gene ID
84152
UniProt
Q9UD71, A0A024R1R3
Accession Number mRNA
NM_181505
Chromosomal Location
17q12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
18.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PPP1R1B
Species
Human
Protein ID
NP_852606
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84152
Uniprot URL
https://www.uniprot.org/uniprot/Q9UD71
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_181505
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_852606
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