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Sodium Potassium ATPase (ATP1A1) (NM_000701) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Synonyms

MGC3285; MGC51750

Gene ID

476

UniProt

P05023

Accession Number mRNA

NM_000701

Chromosomal Location

1p13.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cardiac muscle contraction

Field of Research

Cardiac muscle contraction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

112.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ATP1A1

Species

Human

Protein ID

NP_000692

Overview

Recombinant protein of human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/476

Uniprot URL

https://www.uniprot.org/uniprot/P05023

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000701

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000692

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