Sodium Potassium ATPase (ATP1A1) (NM_000701) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Synonyms
MGC3285; MGC51750
Gene ID
476
UniProt
P05023
Accession Number mRNA
NM_000701
Chromosomal Location
1p13.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cardiac muscle contraction
Field of Research
Cardiac muscle contraction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
112.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ATP1A1
Species
Human
Protein ID
NP_000692
Overview
Recombinant protein of human ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/476
Uniprot URL
https://www.uniprot.org/uniprot/P05023
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000701
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000692
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