Suppressor of Fused (SUFU) (NM_016169) Human Recombinant Protein
Product Specifications
Background
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Overview
Recombinant protein of human suppressor of fused homolog (Drosophila) (SUFU)
Synonyms
JBTS32; PRO1280; SUFUH; SUFUXL
Gene ID
51684
UniProt
Q9UMX1
Accession Number mRNA
NM_016169
Chromosomal Location
10q24.32
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Field of Research
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
53.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SUFU
Species
Human
Protein ID
NP_057253
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51684
Uniprot URL
https://www.uniprot.org/uniprot/Q9UMX1
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016169
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057253
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