COMMD5 (NM_001081004) Human Recombinant Protein
Product Specifications
Background
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237) . Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity) . Down-regulates activation of NF-kappa-B (PubMed:15799966) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human COMM domain containing 5 (COMMD5), transcript variant 3
Synonyms
HCARG; HT002
Gene ID
28991
UniProt
Q9GZQ3
Accession Number mRNA
NM_001081004
Chromosomal Location
8q24.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
24.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
COMMD5
Species
Human
Protein ID
NP_001074473
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/28991
Uniprot URL
https://www.uniprot.org/uniprot/Q9GZQ3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001081004
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001074473
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