ASCL1 (NM_004316) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3') . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
Synonyms
ASH1; bHLHa46; HASH1; MASH1
Gene ID
429
UniProt
P50553
Accession Number mRNA
NM_004316
Chromosomal Location
12q23.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
25.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ASCL1
Species
Human
Protein ID
NP_004307
Overview
Recombinant protein of human achaete-scute complex homolog 1 (Drosophila) (ASCL1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/429
Uniprot URL
https://www.uniprot.org/uniprot/P50553
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004316
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004307
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