TPM4 (NM_003290) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Synonyms
HEL-S-108
Gene ID
7171
UniProt
P67936, V9HW56
Accession Number mRNA
NM_003290
Chromosomal Location
19p13.12-p13.11
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
28.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TPM4
Species
Human
Protein ID
NP_003281
Overview
Recombinant protein of human tropomyosin 4 (TPM4), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7171
Uniprot URL
https://www.uniprot.org/uniprot/P67936
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003290
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003281
Curated Selection
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