FVT1 (KDSR) (NM_002035) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
Synonyms
DHSR; EKVP4; FVT1; SDR35C1
Gene ID
2531
UniProt
Q06136, A0A024R292, B4DMX0
Accession Number mRNA
NM_002035
Chromosomal Location
18q21.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Sphingolipid metabolism
Field of Research
Metabolic pathways, Sphingolipid metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
33.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KDSR
Species
Human
Protein ID
NP_002026
Overview
Recombinant protein of human 3-ketodihydrosphingosine reductase (KDSR)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2531
Uniprot URL
https://www.uniprot.org/uniprot/Q06136
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002035
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002026
Curated Selection
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