FVT1 (KDSR) (NM_002035) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human 3-ketodihydrosphingosine reductase (KDSR)

Synonyms

DHSR; EKVP4; FVT1; SDR35C1

Gene ID

2531

UniProt

Q06136, A0A024R292, B4DMX0

Accession Number mRNA

NM_002035

Chromosomal Location

18q21.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Sphingolipid metabolism

Field of Research

Metabolic pathways, Sphingolipid metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

33.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.