ISG15 (NM_005101) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Overview
Recombinant protein of human ISG15 ubiquitin-like modifier (ISG15)
Synonyms
G1P2; hUCRP; IFI15; IMD38; IP17; UCRP
Gene ID
9636
UniProt
P05161
Accession Number mRNA
NM_005101
Chromosomal Location
1p36.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
RIG-I-like receptor signaling pathway
Field of Research
RIG-I-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
17.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ISG15
Species
Human
Protein ID
NP_005092
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9636
Uniprot URL
https://www.uniprot.org/uniprot/P05161
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005101
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005092
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