M6PR (NM_002355) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Synonyms
CD-M6PR; CD-MPR; MPR-46; MPR 46; MPR46; SMPR
Gene ID
4074
UniProt
P20645
Accession Number mRNA
NM_002355
Chromosomal Location
12p13.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysosome
Field of Research
Lysosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
27.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
M6PR
Species
Human
Protein ID
NP_002346
Overview
Recombinant protein of human mannose-6-phosphate receptor (cation dependent) (M6PR)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4074
Uniprot URL
https://www.uniprot.org/uniprot/P20645
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002355
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002346
Curated Selection
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