DHRS11 (NM_024308) Human Recombinant Protein
Product Specifications
Background
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human dehydrogenase/reductase (SDR family) member 11 (DHRS11)
Synonyms
ARPG836; SDR24C1; spDHRS11
Gene ID
79154
UniProt
Q6UWP2, A0A024R0T1
Accession Number mRNA
NM_024308
Chromosomal Location
17q12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
28.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DHRS11
Species
Human
Protein ID
NP_077284
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/79154
Uniprot URL
https://www.uniprot.org/uniprot/Q6UWP2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_024308
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_077284
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