APPBP1 (NAE1) (NM_001018160) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human NEDD8 activating enzyme E1 subunit 1 (NAE1), transcript variant 3
Synonyms
A-116A10.1; APPBP1; HPP1; ula-1
Gene ID
8883
UniProt
Q13564
Accession Number mRNA
NM_001018160
Chromosomal Location
16q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease
Field of Research
Alzheimer's disease
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
50.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NAE1
Species
Human
Protein ID
NP_001018170
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8883
Uniprot URL
https://www.uniprot.org/uniprot/Q13564
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001018160
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001018170
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470253-500 1x 500 µL
Cytokeratin, LMW (AE-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681081-500 1x 500 µL
CD45RO (190-2F2.5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
