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PP2A-alpha (PPP2CA) (NM_002715) Human Recombinant Protein

Product Specifications

Background

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (PPP2CA)

Synonyms

NEDLBA; PP2Ac; PP2CA; PP2Calpha; RP-C

Gene ID

5515

UniProt

P67775, B3KUN1

Accession Number mRNA

NM_002715

Chromosomal Location

5q31.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway

Field of Research

Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Phosphatase, Transcription Factors

Molecular Weight

35.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PPP2CA

Species

Human

Protein ID

NP_002706

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5515

Uniprot URL

https://www.uniprot.org/uniprot/P67775

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002715

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002706

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