SIGIRR (NM_021805) Human Recombinant Protein
Selected Variant
PH41480M5
Size: 20 µg
Product Specifications
Background
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Homo sapiens single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR), transcript variant 3
Synonyms
IL-1R8; TIR8
Gene ID
59307
UniProt
Q6IA17
Accession Number mRNA
NM_021805
Chromosomal Location
11p15.5
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors, Transmembrane
Molecular Weight
45.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SIGIRR
Species
Human
Protein ID
NP_068577
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/59307
Uniprot URL
https://www.uniprot.org/uniprot/Q6IA17
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021805
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_068577
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