RITA (RITA1) (NM_032848) Human Recombinant Protein
Product Specifications
Background
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.[UniProtKB/Swiss-Prot Function]
Synonyms
C12orf52; RITA
Gene ID
84934
UniProt
Q96K30, A0A024RBL1
Accession Number mRNA
NM_032848
Chromosomal Location
12q24.13
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
28.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RITA1
Species
Human
Protein ID
NP_116237
Overview
Recombinant protein of human chromosome 12 open reading frame 52 (C12orf52)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84934
Uniprot URL
https://www.uniprot.org/uniprot/Q96K30
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032848
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_116237
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