Argininosuccinate Lyase (ASL) (NM_001024943) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human argininosuccinate lyase (ASL), transcript variant 1
Synonyms
ASAL
Gene ID
435
UniProt
P04424, A0A024RDL8
Accession Number mRNA
NM_001024943
Chromosomal Location
7q11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways
Field of Research
Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
51.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ASL
Species
Human
Protein ID
NP_001020114
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/435
Uniprot URL
https://www.uniprot.org/uniprot/P04424
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001024943
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001020114
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