Beclin 1 (BECN1) (NM_003766) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Synonyms
ATG6; beclin1; VPS30
Gene ID
8678
UniProt
Q14457, A0A024R1X5
Accession Number mRNA
NM_003766
Chromosomal Location
17q21.31
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Regulation of autophagy
Field of Research
Regulation of autophagy
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
25642769
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
51.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BECN1
Species
Human
Protein ID
NP_003757
Overview
Recombinant protein of human beclin 1, autophagy related (BECN1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8678
Uniprot URL
https://www.uniprot.org/uniprot/Q14457
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003766
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003757
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