Beclin 1 (BECN1) (NM_003766) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Overview

Recombinant protein of human beclin 1, autophagy related (BECN1)

Synonyms

ATG6; beclin1; VPS30

Gene ID

8678

UniProt

Q14457, A0A024R1X5

Accession Number mRNA

NM_003766

Chromosomal Location

17q21.31

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Regulation of autophagy

Field of Research

Regulation of autophagy

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

25642769

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

51.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.