CIRBP (NM_001280) Human Recombinant Protein
Product Specifications
Background
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity) . Promotes assembly of stress granules (SGs), when overexpressed.[UniProtKB/Swiss-Prot Function]
Synonyms
CIRP
Gene ID
1153
UniProt
Q14011, Q53XX5
Accession Number mRNA
NM_001280
Chromosomal Location
19p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
18.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CIRBP
Species
Human
Protein ID
NP_001271
Overview
Recombinant protein of human cold inducible RNA binding protein (CIRBP), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1153
Uniprot URL
https://www.uniprot.org/uniprot/Q14011
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001280
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001271
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