LANPL (ANP32E) (NM_030920) Human Recombinant Protein
Product Specifications
Background
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511) . Inhibits activity of protein phosphatase 2A (PP2A) . Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E), transcript variant 1
Synonyms
LANP-L; LANPL
Gene ID
81611
UniProt
Q9BTT0
Accession Number mRNA
NM_030920
Chromosomal Location
1q21.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
30.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ANP32E
Species
Human
Protein ID
NP_112182
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/81611
Uniprot URL
https://www.uniprot.org/uniprot/Q9BTT0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_030920
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_112182
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