TFB2M (NM_022366) Human Recombinant Protein
Product Specifications
Background
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.[UniProtKB/Swiss-Prot Function]
Synonyms
Hkp1; mtTFB2
Gene ID
64216
UniProt
Q9H5Q4
Accession Number mRNA
NM_022366
Chromosomal Location
1q44
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
45.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TFB2M
Species
Human
Protein ID
NP_071761
Overview
Recombinant protein of human transcription factor B2, mitochondrial (TFB2M), nuclear gene encoding mitochondrial protein
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64216
Uniprot URL
https://www.uniprot.org/uniprot/Q9H5Q4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022366
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071761
Curated Selection
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