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CBS (NM_000071) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Synonyms

CBSL; HIP4

Gene ID

875

UniProt

P35520, P0DN79, Q9NTF0

Accession Number mRNA

NM_000071

Chromosomal Location

21q22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Selenoamino acid metabolism

Field of Research

Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Selenoamino acid metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

60.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CBS

Species

Human

Protein ID

NP_000062

Overview

Recombinant protein of human cystathionine-beta-synthase (CBS)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/875

Uniprot URL

https://www.uniprot.org/uniprot/P35520

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000071

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000062

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