Alpha 1 Catenin (CTNNA1) (NM_001903) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
Synonyms
CAP102; MDPT2
Gene ID
1495
UniProt
P35221, A0A384MDY0
Accession Number mRNA
NM_001903
Chromosomal Location
5q31.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction
Field of Research
Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Endometrial cancer, Leukocyte transendothelial migration, Pathways in cancer, Tight junction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
99.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CTNNA1
Species
Human
Protein ID
NP_001894
Overview
Recombinant protein of human catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1495
Uniprot URL
https://www.uniprot.org/uniprot/P35221
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001903
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001894
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