HEAB (CLP1) (NM_006831) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10) . Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Synonyms
HClp1; HEAB
Gene ID
10978
UniProt
Q92989
Accession Number mRNA
NM_006831
Chromosomal Location
11q12.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
47.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CLP1
Species
Human
Protein ID
NP_006822
Overview
Recombinant protein of human CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) (CLP1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10978
Uniprot URL
https://www.uniprot.org/uniprot/Q92989
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006831
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006822
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