RAB7 (RAB7A) (NM_004637) Human Recombinant Protein
Product Specifications
Background
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human RAB7A, member RAS oncogene family (RAB7A)
Synonyms
CMT2B; PRO2706; RAB7
Gene ID
7879
UniProt
P51149, A0A158RFU6
Accession Number mRNA
NM_004637
Chromosomal Location
3q21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
23.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RAB7A
Species
Human
Protein ID
NP_004628
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7879
Uniprot URL
https://www.uniprot.org/uniprot/P51149
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004637
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004628
Curated Selection
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