U1A (SNRPA) (NM_004596) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
Synonyms
Mud1; U1-A; U1A
Gene ID
6626
UniProt
P09012
Accession Number mRNA
NM_004596
Chromosomal Location
19q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Spliceosome
Field of Research
Spliceosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
Leading Biology human recombinant small nuclear ribonucleoprotein polypeptide A (SNRPA) was compared side-by-side with baculovirus based insect cell (BEVS) derived SNRPA in a phycoerythrin detecting Luminex assay. The human cell produced SNRPA is comparative or better in sensitivity than the insect cell produced SNRPA to detect autoantibodies in human serum samples.
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Stem cell - Pluripotency
Molecular Weight
31.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SNRPA
Species
Human
Protein ID
NP_004587
Overview
Recombinant protein of human small nuclear ribonucleoprotein polypeptide A (SNRPA)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6626
Uniprot URL
https://www.uniprot.org/uniprot/P09012
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004596
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004587
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