GPBB (PYGB) (NM_002862) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human phosphorylase, glycogen; brain (PYGB)
Synonyms
GPBB
Gene ID
5834
UniProt
P11216
Accession Number mRNA
NM_002862
Chromosomal Location
20p11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Insulin signaling pathway, Starch and sucrose metabolism
Field of Research
Insulin signaling pathway, Starch and sucrose metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
96.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PYGB
Species
Human
Protein ID
NP_002853
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5834
Uniprot URL
https://www.uniprot.org/uniprot/P11216
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002862
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002853
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