Alpha 1 Antitrypsin (SERPINA1) (NM_000295) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]

Overview

Recombinant protein of human serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 1

Synonyms

A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1; PRO2275

Gene ID

5265

UniProt

P01009, E9KL23

Accession Number mRNA

NM_000295

Chromosomal Location

14q32.13

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Complement and coagulation cascades

Field of Research

Complement and coagulation cascades

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

2626562927936229

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein

Molecular Weight

44.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.