ICA1 (NM_004968) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Overview
Recombinant protein of human islet cell autoantigen 1, 69kDa (ICA1), transcript variant 2
Synonyms
ICA69; ICAp69
Gene ID
3382
UniProt
Q05084, A0A024RA29
Accession Number mRNA
NM_004968
Chromosomal Location
7p21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Type I diabetes mellitus
Field of Research
Type I diabetes mellitus
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
54.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ICA1
Species
Human
Protein ID
NP_004959
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3382
Uniprot URL
https://www.uniprot.org/uniprot/Q05084
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004968
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004959
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