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ICA1 (NM_004968) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Overview

Recombinant protein of human islet cell autoantigen 1, 69kDa (ICA1), transcript variant 2

Synonyms

ICA69; ICAp69

Gene ID

3382

UniProt

Q05084, A0A024RA29

Accession Number mRNA

NM_004968

Chromosomal Location

7p21.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Type I diabetes mellitus

Field of Research

Type I diabetes mellitus

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

54.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ICA1

Species

Human

Protein ID

NP_004959

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3382

Uniprot URL

https://www.uniprot.org/uniprot/Q05084

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004968

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004959

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