Endothelin 1 (EDN1) (NM_001955) Human Recombinant Protein
Product Specifications
Background
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Overview
Recombinant protein of human endothelin 1 (EDN1)
Synonyms
ARCND3; ET1; HDLCQ7; PPET1; QME
Gene ID
1906
UniProt
P05305, Q6FH53
Accession Number mRNA
NM_001955
Chromosomal Location
6p24.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Melanogenesis
Field of Research
Melanogenesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
22.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EDN1
Species
Human
Protein ID
NP_001946
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1906
Uniprot URL
https://www.uniprot.org/uniprot/P05305
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001955
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001946
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