MYD88 (NM_002468) Human Recombinant Protein

Product Specifications

Background

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Overview

Recombinant protein of human myeloid differentiation primary response gene (88) (MYD88)

Synonyms

IMD68; MYD88D

Gene ID

4615

UniProt

Q99836, A0A0A0MS70

Accession Number mRNA

NM_002468

Chromosomal Location

3p22.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Apoptosis, Toll-like receptor signaling pathway

Field of Research

Apoptosis, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

33.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.