Apoptosis enhancing nuclease (AEN) (NM_022767) Human Recombinant Protein
Product Specifications
Background
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human apoptosis enhancing nuclease (AEN)
Synonyms
ISG20L1; pp12744
Gene ID
64782
UniProt
Q8WTP8
Accession Number mRNA
NM_022767
Chromosomal Location
15q26.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
36.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AEN
Species
Human
Protein ID
NP_073604
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64782
Uniprot URL
https://www.uniprot.org/uniprot/Q8WTP8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022767
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_073604
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